Lindsey (Les) Shaw
Professor
Lindsey N. Shaw, Ph.D. is a Professor in the Department of Molecular Biosciences and holds joint appointments in the departments of Infectious Disease and Global Health. Dr Shaw is also the Richard and Patricia Wood Endowed Chair in Natural Sciences and Director of the USF Center for Antimicrobial Resistance. Dr. Shaw's research focuses on the pathogenic and drug resistance mechanisms ofantibiotic resistantbacteria, with a primary focus on Methicillin Resistant Staphylococcus aureus (MRSA), as well as the other ESKAPE pathogens. He has made significant advances in defining the regulatory processes ongoing within bacteria cells that contribute to virulence factor expression and the progression of disease. His groundbreaking discovery of secreted proteases as key mediators of MRSA pathogenic potential was a turning point in the field as it identified a key node of control that governs the infectious process. In the area of therapeutic development, Dr. Shaw was part of a team that isolated and identified a new chemical, Darwinolide, which eliminates more than 98 percent of MRSA cells growing within a biofilm. He is also amongst the small percentage of NIH awardees who have been a Principal Investigator on an R01 grant before the age of 36. Dr. Shaw received a B.Sc. with honors from the University of East Anglia (U.K.) and a Ph.D. from the University of Sheffield (U.K.).
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